{"id":46,"date":"2024-07-07T05:01:43","date_gmt":"2024-07-07T05:01:43","guid":{"rendered":"https:\/\/neuronanobiophysics.utsa.edu\/?page_id=46"},"modified":"2026-04-05T16:01:37","modified_gmt":"2026-04-05T16:01:37","slug":"cytoskelon-filaments","status":"publish","type":"page","link":"https:\/\/neuronanobiophysics.utsa.edu\/?page_id=46","title":{"rendered":"Cytoskeleton Filaments"},"content":{"rendered":"<p class=\"has-text-align-left\" style=\"text-align: justify;\">F-actins and MTs are highly charged cytoskeleton filaments that transmit electric signals, sustain ionic conductance, and overcome electrostatic interactions to form higher-order structures (bundles and networks). They carry out biological activities in eukaryotic cellular processes as diverse as directional growth, shape, division, plasticity, and migration. The basis for these filaments to form higher-order structures and enhance their electrical conductivity appears primarily or exclusively dominated by their biochemical and biophysical (polyelectrolyte) properties. However, the underlying principles supporting the polyelectrolyte nature of MTs and F-actin, and the anomalies in their biological functions associated with aging and inherited conditions, remain poorly understood. Thus, an accurate and efficient characterization of polyelectrolyte properties for cytoskeleton filaments is key to the molecular understanding of electrical signal propagation, bundle and network formation, and their potential nanotechnological applications under different conditions. Current experimental techniques are limited in resolution and sensitivity for obtaining information on the molecular mechanisms governing these phenomena.<\/p>\n<p class=\"has-text-align-left\" style=\"text-align: justify;\">Our theoretical studies of cytoskeleton filaments under normal conditions reveal that a nontrivial balance and competition between electromechanical interactions are responsible for the stability, bundling, and conducting properties of these filaments. Accordingly, molecular or cellular alterations often evident in pathological conditions might disrupt this balance and competition, leading to cytoskeletal filament dysfunctions such as dysregulated assembly, aberrant protein binding, altered polymerization stability, and defective electrical signal transmission.<\/p>\n<p><a href=\"https:\/\/reporter.nih.gov\/project-details\/9700171\" target=\"_blank\" rel=\"noopener\">More information<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-48 size-full\" src=\"https:\/\/neuronanobiophysics.utsa.edu\/wp-content\/uploads\/2024\/07\/figureinterview2-1024x576-1.png\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/neuronanobiophysics.utsa.edu\/wp-content\/uploads\/2024\/07\/figureinterview2-1024x576-1.png 1024w, https:\/\/neuronanobiophysics.utsa.edu\/wp-content\/uploads\/2024\/07\/figureinterview2-1024x576-1-300x169.png 300w, https:\/\/neuronanobiophysics.utsa.edu\/wp-content\/uploads\/2024\/07\/figureinterview2-1024x576-1-768x432.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>F-actins and MTs are highly charged cytoskeleton filaments that transmit electric signals, sustain ionic conductance, and overcome electrostatic interactions to form higher-order structures (bundles and networks). They carry out biological activities in eukaryotic cellular processes as diverse as directional growth, shape, division, plasticity, and migration. The basis for these filaments to form higher-order structures and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-46","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=\/wp\/v2\/pages\/46","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46"}],"version-history":[{"count":8,"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=\/wp\/v2\/pages\/46\/revisions"}],"predecessor-version":[{"id":172,"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=\/wp\/v2\/pages\/46\/revisions\/172"}],"wp:attachment":[{"href":"https:\/\/neuronanobiophysics.utsa.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}