Welcome to Dr. Marucho’s Research Group Website!

By using comprehensive computer models and high performance algorithms, we develop theories and software to produce valuable data for elucidating the molecular mechanisms underlying the electrical signal propagation, stability and bundle formation of actin filaments under different molecular (wild type, isoforms, mutants) and environmental (physiological and non-physiological) conditions. As a unique feature, we provide experts and non-experts in the field a visualized guide (graphical user interface) to perform these calculations online without computational restrictions. Ultimately, these studies may figure out whether molecular and cellular alterations substantially alter the equilibrium of interactions and trigger abnormalities in the bundling and signal propagation during various disease states.